Protein C, protein S and antithrombin III deficiencies in retinal vein occlusion

Deficiencies of natural anticoagulants, protein C, protein S, and antithrombin.

Y ou or a family member may have developed a blood clot in one of the deep veins in the body (ie, a deep vein thrombosis, or DVT) or had a blood clot that traveled to the lungs (ie, a pulmonary embolism, or PE). As part of your medical care, your doctor may have evaluated you for conditions that may have contributed to developing a blood clot. Thrombophilia is a condition in which there is an i...

Activated protein C and retinal vein occlusion.

Genetic characterization of antithrombin, protein C, and protein S deficiencies in Polish patients.

INTRODUCTION    Inherited deficiencies of natural anticoagulants such as antithrombin (AT; gene: SERPINC1), protein C (PC; PROC), and protein S (PS; PROS1), with the prevalence in the general European population of 0.02% to 0.17%, 0.2% to 0.3%, and 0.5%, respectively, are associated with increased risk of thromboembolic events. Only a few case reports of Polish deficient patients with known cau...

Thrombosis in inherited deficiencies of antithrombin, protein C, and protein S.

The coagulation cascade can be pictured as a series of reactions in which a zymogen, a cofactor, and a converting enzyme interact to form a multimolecular complex on a natural surface. In each case, the four reactants must be present if the conversion of a zymogen to the corresponding serine protease is to take place at any significant rate. The principal natural anticoagulant systems that are ...

Diagnosis of activated protein C resistance in retinal vein occlusion.

EDITOR,—I read with interest the article published in the BJO by Hunt. 1 In this paper the author reports that the prevalence of APC resistance is more common than any other known thrombophilic state and was present in over one third of patients younger than 45 years with central retinal vein occlusion (CRVO). Therefore, many would argue that a full thrombophilia screening should be performed i...